A bloody mess: dendritic cells use hemophagocytosis to regulate viral inflammation

Elizabeth Miller; Nina Bhardwaj

doi:10.1016/j.immuni.2013.08.024

A bloody mess: dendritic cells use hemophagocytosis to regulate viral inflammation

Immunity. 2013 Sep 19;39(3):429-31. doi: 10.1016/j.immuni.2013.08.024.

Authors

Elizabeth Miller¹, Nina Bhardwaj

Affiliation

¹ Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

Previous studies have highlighted the immune-dampening effects of apoptotic cell uptake by phagocytes. Ohyagi et al. (2013) expose a unique mechanism of immune regulation during viral infection, which is mediated through phagocytosis of apoptotic red cells by dendritic cells.

Publication types

Comment

MeSH terms

Animals
Apoptosis / immunology*
Dendritic Cells / immunology*
Lymphocytic choriomeningitis virus / immunology*
Phagocytosis*

Grants and funding

R37 AI044628/AI/NIAID NIH HHS/United States