Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

J Neuroimmunol. 2013 Nov 15;264(1-2):24-34. doi: 10.1016/j.jneuroim.2013.08.014. Epub 2013 Sep 1.

Abstract

The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised.

Keywords: BDNF; Exercise; Experimental autoimmune encephalomyelitis; Intravital microscopy; Neuroinflammation; Neuroprotection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Brain / metabolism*
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Cytokines / metabolism*
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental / chemically induced
  • Encephalomyelitis, Autoimmune, Experimental / metabolism
  • Encephalomyelitis, Autoimmune, Experimental / pathology*
  • Encephalomyelitis, Autoimmune, Experimental / rehabilitation*
  • Enzyme-Linked Immunosorbent Assay
  • Exercise Therapy / methods*
  • Female
  • Freund's Adjuvant / toxicity
  • Leukocyte Count
  • Mice
  • Mice, Inbred C57BL
  • Myelin-Oligodendrocyte Glycoprotein / toxicity
  • Peptide Fragments / toxicity
  • Physical Conditioning, Animal / methods
  • Spinal Cord / metabolism*
  • Swimming
  • Time Factors

Substances

  • Brain-Derived Neurotrophic Factor
  • Cytokines
  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments
  • myelin oligodendrocyte glycoprotein (35-55)
  • Freund's Adjuvant