Abstract
Chemical investigation from roots of Enkleia siamensis (Kurz) Nervling resulted in the isolation of 10 compounds. Their structures were established on the basis of 1D and 2D NMR spectroscopic data as linobiflavonoid (1), chamaejasmin (2), 7-O-β-D-glucopyranosylchamaejasmin (3), ormocarpin (4), (-)-wikstromol (5), matairesinol (6), (+)-lariciresinol (7), umbelliferone (8), daphnoretin (9) and carthamidin (10). Compounds 2 and 8 showed cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines. Compounds 1, 2 and 5 showed weak minimum inhibitory requirements to acetylcholinesterase with values ranging from 50 to 1000 ng. In addition, compound 2 exhibited antimalarial activity against Plasmodium falciparum with an IC50 value of 2.32 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Biflavonoids / chemistry
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Biflavonoids / isolation & purification*
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Biflavonoids / pharmacology*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification
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Coumarins / isolation & purification
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Drug Screening Assays, Antitumor
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Flavonoids
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Furans / isolation & purification
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Humans
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KB Cells
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Lignans / isolation & purification
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plasmodium falciparum / drug effects*
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Thailand
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Thymelaeaceae / chemistry*
Substances
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Biflavonoids
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Cholinesterase Inhibitors
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Coumarins
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Flavonoids
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Furans
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Lignans
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chamaejasmin
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linobiflavonoid
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daphnoretin
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matairesinol
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nortrachelogenin
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lariciresinol