Abstract
Phytochemical investigation of the leaves of Pittosporum angustifolium resulted in the isolation and structural elucidation of nine new triterpene saponins, named pittangretosides A-I (1-9), together with a known compound (10). Mainly by NMR and HRESIMS experiments, eight compounds were identified as A1-barrigenol glycosides (1-7, 10), whereas two compounds exhibited an unusual 17,22-seco-backbone of oleanolic acid (8, 9). All compounds were evaluated for their in vitro cytotoxicities against human urinary bladder carcinoma cells (5637). Only compounds with an angeloyl-residue at C-22 of the aglycone (1-4 and 10) showed antiproliferative effects with IC50 values of 4.1, 5.2, 2.1, 17.9, and 2.4 µM, respectively.
Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Carcinoma / drug therapy
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Glycosides / therapeutic use
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Oleanolic Acid / chemistry
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Phytotherapy
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plant Leaves / chemistry*
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Rosales / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Triterpenes / therapeutic use
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Urinary Bladder Neoplasms / drug therapy
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Plant Extracts
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Triterpenes
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Oleanolic Acid