Abstract
Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems will require re-engineering central components of the protein synthesis machinery on the basis of a solid mechanistic biochemical understanding of the synthetic process.
MeSH terms
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Amino Acids / chemistry
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Amino Acids / genetics
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Amino Acids / metabolism
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Genetic Code / genetics
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Molecular Conformation
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Protein Biosynthesis / genetics*
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Proteins / chemistry
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Proteins / genetics*
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Proteins / metabolism*
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RNA, Transfer / chemistry
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RNA, Transfer / metabolism
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Synthetic Biology*
Substances
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Amino Acids
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Proteins
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RNA, Transfer