Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

Chem Commun (Camb). 2013 Nov 4;49(85):10022-4. doi: 10.1039/c3cc46070c.

Abstract

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Chloroform / chemistry*
  • Hydrogenation
  • Ketones / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Ruthenium / chemistry
  • Stereoisomerism

Substances

  • Amides
  • Amines
  • Ketones
  • Ruthenium
  • Chloroform