Abstract
Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry*
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Amines / chemistry*
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Catalysis
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Chloroform / chemistry*
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Hydrogenation
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Ketones / chemistry*
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Molecular Structure
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Oxidation-Reduction
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Ruthenium / chemistry
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Stereoisomerism
Substances
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Amides
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Amines
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Ketones
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Ruthenium
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Chloroform