Abstract
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Auranofin / chemistry*
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Auranofin / metabolism
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Binding Sites
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Crystallography, X-Ray
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Drug Design
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Gold / chemistry*
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Gold / classification
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Gold / metabolism
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Models, Molecular
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Molecular Structure
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Muramidase / chemistry*
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Muramidase / metabolism
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Protein Binding
Substances
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Antineoplastic Agents
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Organometallic Compounds
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Auranofin
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Gold
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hen egg lysozyme
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Muramidase