Unilateral livedoid vasculopathy associated with involutional phase of cutaneous infantile hemangioma: the connection to coagulation disorders

Int J Low Extrem Wounds. 2013 Dec;12(4):306-9. doi: 10.1177/1534734613502049. Epub 2013 Sep 16.

Abstract

Livedoid vasculopathy is a bilateral painful and recurrent cutaneous ulcerative disorder of the legs that leads to atrophie blanche, atrophic white-porcelain scars, and is associated with disorders of fibrinolysis and/or coagulation. We present a young boy with an association between livedoid vasculopathy in the area of a previous involuted cutaneous hemangioma. We found 4 uncommon abnormalities associated with thrombo-occlusive events: heterozygous 20210 A→G genotype of prothrombin, reduced activity of anticoagulation proteins C and S, and elevated lipoprotein (a).

Keywords: atrophie blanche; hemangioma; livedoid vasculopathy.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aspirin / administration & dosage*
  • Biopsy
  • Blood Coagulation Disorders / complications*
  • Blood Coagulation Disorders / diagnosis
  • Blood Coagulation Disorders / physiopathology
  • Blood Coagulation Tests
  • Diagnosis, Differential
  • Hemangioma / complications*
  • Hemangioma / diagnosis
  • Hemangioma / physiopathology
  • Histological Techniques / methods
  • Humans
  • Leg Ulcer* / etiology
  • Leg Ulcer* / pathology
  • Leg Ulcer* / physiopathology
  • Livedo Reticularis* / diagnosis
  • Livedo Reticularis* / drug therapy
  • Livedo Reticularis* / etiology
  • Livedo Reticularis* / physiopathology
  • Male
  • Pentoxifylline / administration & dosage*
  • Platelet Aggregation Inhibitors / administration & dosage
  • Prothrombin / genetics
  • Skin Neoplasms / complications*
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / physiopathology
  • Treatment Outcome
  • Ultrasonography, Doppler / methods

Substances

  • Platelet Aggregation Inhibitors
  • Prothrombin
  • Aspirin
  • Pentoxifylline