A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors

Chem Commun (Camb). 2013 Nov 4;49(85):10007-9. doi: 10.1039/c3cc45743e.

Abstract

A new paullone-TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Benzazepines / chemistry*
  • Benzazepines / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology
  • Copper / chemistry*
  • Cyclic N-Oxides / chemistry*
  • Free Radicals / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Ligands
  • Molecular Structure
  • Orphan Nuclear Receptors / antagonists & inhibitors*
  • Reactive Oxygen Species

Substances

  • Antineoplastic Agents
  • Benzazepines
  • Coordination Complexes
  • Cyclic N-Oxides
  • Free Radicals
  • Ligands
  • NR2E3 protein, human
  • Orphan Nuclear Receptors
  • Reactive Oxygen Species
  • paullone
  • Copper
  • TEMPO