Abstract
A new paullone-TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Benzazepines / chemistry*
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Benzazepines / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacology
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Copper / chemistry*
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Cyclic N-Oxides / chemistry*
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Free Radicals / chemistry
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Humans
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Inhibitory Concentration 50
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Ligands
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Molecular Structure
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Orphan Nuclear Receptors / antagonists & inhibitors*
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Reactive Oxygen Species
Substances
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Antineoplastic Agents
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Benzazepines
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Coordination Complexes
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Cyclic N-Oxides
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Free Radicals
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Ligands
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NR2E3 protein, human
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Orphan Nuclear Receptors
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Reactive Oxygen Species
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paullone
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Copper
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TEMPO