New triterpenoid estersaponins from the root barks of Pittosporum verticillatum subsp. verticillatum and evaluation of cytotoxicities

Fitoterapia. 2013 Dec:91:231-235. doi: 10.1016/j.fitote.2013.09.002. Epub 2013 Sep 13.

Abstract

The phytochemical investigation of the root barks of Pittosporum verticillatum Bojer subsp. verticillatum led to the isolation of three new triterpene saponins, 3-O-[β-D-glucopyranosyl-(1→2)]-[α-L-arabinopyranosyl-(1→3)]-[α-L-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl-21-O-(2-acetoxy-2-methylbutanoyl)-R1-barrigenol (1), 3-O-[β-D-glucopyranosyl-(1→2)]-[α-L-arabinopyranosyl-(1→3)]-[α-L-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl-21-O-(2-acetoxy-2-methylbutanoyl)-28-O-acetyl-R1-barrigenol (2), 3-O-[β-D-glucopyranosyl-(1→2)]-[α-L-arabinopyranosyl-(1→3)]-[α-L-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl-21-O-β,β-dimethylacryloyl-22-O-angeloyl-R1-barrigenol (3), and one known saponin senaciapittoside B (4). Their structures were elucidated mainly by 1D- and 2D-NMR spectroscopy and HRESIMS. Compounds 1-4 were evaluated for their cytotoxicity against one human cancer cell line (SW480) and one rat cardiomyoblast cell line (H9c2).

Keywords: Cytotoxicity; Pittosporaceae; Pittosporum verticillatum; Triterpene saponin.

MeSH terms

  • Animals
  • Cell Line
  • Cell Line, Tumor
  • Humans
  • Molecular Structure
  • Neoplasms* / drug therapy
  • Plant Bark / chemistry
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Rats
  • Rosales / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • 3-O-(glucopyranosyl-(1-2))-(arabinopyranosyl-(1-3))-(arabinofuranosyl-(1-4))-glucuronopyranosyl-21-O-beta,beta-dimethylacryloyl-22-O-angeloyl-R1-barrigenol
  • Plant Extracts
  • Saponins
  • Triterpenes
  • senaciapittoside B