Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

ChemMedChem. 2013 Oct;8(10):1634-7. doi: 10.1002/cmdc.201300276. Epub 2013 Aug 23.

Abstract

Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.

Keywords: Leishmania; antiprotozoal agents; gold; inhibitors; trypanothione reductase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiprotozoal Agents / chemical synthesis
  • Antiprotozoal Agents / chemistry*
  • Antiprotozoal Agents / pharmacology
  • Catalytic Domain
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Gold / chemistry*
  • Kinetics
  • Leishmania / drug effects
  • Leishmania / enzymology
  • Molecular Docking Simulation
  • NADH, NADPH Oxidoreductases / antagonists & inhibitors*
  • NADH, NADPH Oxidoreductases / metabolism
  • Protein Binding

Substances

  • Antiprotozoal Agents
  • Coordination Complexes
  • Enzyme Inhibitors
  • Gold
  • NADH, NADPH Oxidoreductases
  • trypanothione reductase