Abstract
Stay on Target: The cucurbit[7]uril derivative 1 which bears a covalently attached biotin targeting ligand allows for the efficient delivery of oxaliplatin as its 1•oxaliplatin complex to cancer cells resulting in enhanced cytotoxicity relative to oxaliplatin alone.
Keywords:
biotin; cucurbit[n]uril; drug delivery; host-guest chemistry; oxaliplatin.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Biotin / chemistry
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Bridged-Ring Compounds / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Carriers / chemistry*
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Imidazoles / chemistry*
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Mice
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Microscopy, Confocal
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / toxicity
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Oxaliplatin
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
Substances
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Bridged-Ring Compounds
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Drug Carriers
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Imidazoles
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Organoplatinum Compounds
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Repressor Proteins
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biotin repressor
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cucurbit(7)uril
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Oxaliplatin
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Biotin