Cucurbit[7]uril containers for targeted delivery of oxaliplatin to cancer cells

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12033-7. doi: 10.1002/anie.201305061. Epub 2013 Sep 13.

Abstract

Stay on Target: The cucurbit[7]uril derivative 1 which bears a covalently attached biotin targeting ligand allows for the efficient delivery of oxaliplatin as its 1•oxaliplatin complex to cancer cells resulting in enhanced cytotoxicity relative to oxaliplatin alone.

Keywords: biotin; cucurbit[n]uril; drug delivery; host-guest chemistry; oxaliplatin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biotin / chemistry
  • Bridged-Ring Compounds / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Carriers / chemistry*
  • Imidazoles / chemistry*
  • Mice
  • Microscopy, Confocal
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / toxicity
  • Oxaliplatin
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism

Substances

  • Bridged-Ring Compounds
  • Drug Carriers
  • Imidazoles
  • Organoplatinum Compounds
  • Repressor Proteins
  • biotin repressor
  • cucurbit(7)uril
  • Oxaliplatin
  • Biotin