Rapid and efficient trifluoromethylation of aromatic and heteroaromatic compounds using potassium trifluoroacetate enabled by a flow system

Abstract

Going to the source: The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF3 CO2 K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF3 ] sources.

Keywords: copper; cross-coupling; flow chemistry; fluorine; synthetic methods.