Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking

Macromol Rapid Commun. 2013 Oct;34(19):1542-6. doi: 10.1002/marc.201300439. Epub 2013 Sep 3.

Abstract

Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated.

Keywords: dendritic cells; glycopolymer-lectin interactions; glycopolymers; glycopolypeptides; resonance; surface plasmon.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circular Dichroism
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism*
  • Glycopeptides / chemical synthesis
  • Glycopeptides / chemistry
  • Glycopeptides / metabolism*
  • HIV Envelope Protein gp120 / antagonists & inhibitors
  • HIV Envelope Protein gp120 / metabolism*
  • HIV-1 / metabolism*
  • Humans
  • Kinetics
  • Lectins / metabolism
  • Polymers / chemistry
  • Protein Binding
  • Protein Structure, Secondary
  • Surface Plasmon Resonance

Substances

  • Glycopeptides
  • HIV Envelope Protein gp120
  • Lectins
  • Polymers