Ultrabright organic dots with aggregation-induced emission characteristics for real-time two-photon intravital vasculature imaging

Abstract

Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner.

Keywords: aggregation-induced emission; blood vascular imaging; nanoparticles; quantum dots; two-photon fluorescence imaging.