Two new sphingolipids from the leaves of Piper betle L

Molecules. 2013 Sep 12;18(9):11241-9. doi: 10.3390/molecules180911241.

Abstract

Two new sphingolipids, pipercerebrosides A (1) and B (2), were isolated from the leaves of Piper betle L. Their structures, including absolute configurations, were determined by spectroscopic analysis and chemical degradation. These two compounds did not show significant cytotoxic activity against the cancer cell lines K562 and HL-60 in a MTT assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • HL-60 Cells
  • Humans
  • K562 Cells
  • Methylation
  • Molecular Structure
  • Oxidation-Reduction
  • Piper betle / chemistry*
  • Plant Leaves / chemistry*
  • Sphingolipids / chemistry*
  • Sphingolipids / isolation & purification
  • Sphingolipids / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Sphingolipids
  • pipercerebroside A
  • pipercerebroside B