Mutagenic and genotoxic effects of aqueous extracts of Achyrocline satureoides in prokaryotic organisms

Mutat Res. 1990 Jan;240(1):13-8. doi: 10.1016/0165-1218(90)90003-k.

Abstract

Aqueous extracts of Achyrocline satureoides (Marcela and/or Macela) were tested for the presence of genotoxic activity in microorganisms. This species belongs to the family Compositae and is used on a large scale by the population of South Brazil. The extracts showed genotoxic activity in the presence of S9 mix in the Ames test TA100, TA98 and TA102 strains, 'SOS' spot chromotest and Microscreen phage-induction assay. The positive results were related to the presence of quercetin and caffeic acid in the aqueous extracts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacteriophages / drug effects
  • Microsomes, Liver / drug effects
  • Molecular Structure
  • Mutagens*
  • Plant Extracts / toxicity*
  • Rats
  • Rats, Inbred Strains
  • SOS Response, Genetics / drug effects
  • Salmonella typhimurium / drug effects
  • Virus Activation / drug effects

Substances

  • Mutagens
  • Plant Extracts