Mucous membrane pemphigoid

Dent Clin North Am. 2013 Oct;57(4):611-30. doi: 10.1016/j.cden.2013.07.003. Epub 2013 Aug 15.

Abstract

Mucous membrane pemphigoid (MMP) is chronic and frequently associated with exacerbations and remissions of clinical signs and symptoms. Clinicians should use pathologic and immunonologic techniques to help diagnose patients. Multidisciplinary collaboration is often necessary for the diagnosis and proper treatment of MMP. Systemic adjuvant immunosuppressive therapy is necessary for patients with progressive disease. In spite of the advances in available immunosuppressive medications and biologics, scarring is a significant complication in many cases. Surgical intervention is not curable; however, it may be necessary for restoring function and improving quality of life.

Keywords: Cicatricial pemphigoid; Mucous membrane; Ocular; Oral; Subepithelial autoimmune disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Conjunctiva / pathology*
  • Diagnosis, Differential
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Mucous Membrane / pathology*
  • Pemphigoid, Benign Mucous Membrane* / drug therapy
  • Pemphigoid, Benign Mucous Membrane* / immunology
  • Pemphigoid, Benign Mucous Membrane* / physiopathology

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal
  • Immunosuppressive Agents