Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major

Br J Haematol. 2013 Nov;163(3):400-3. doi: 10.1111/bjh.12517. Epub 2013 Aug 16.

Abstract

This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in treatment in most subjects. Heart T2* was confirmed to be highly predictive over 1 year for heart failure and arrhythmias. The choice of chelation regimens known to remove heart iron efficiently was not sufficient by itself to influence the risk. Compliance with treatment had a more remarkable role.

Keywords: arrhythmia; beta thalassaemia major; compliance; heart failure; heart magnetic resonance imaging.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Area Under Curve
  • Arrhythmias, Cardiac / epidemiology
  • Arrhythmias, Cardiac / etiology*
  • Arrhythmias, Cardiac / prevention & control
  • Benzoates / administration & dosage
  • Benzoates / therapeutic use
  • Chelation Therapy / methods*
  • Deferasirox
  • Deferiprone
  • Deferoxamine / administration & dosage
  • Deferoxamine / therapeutic use
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Heart Failure / epidemiology
  • Heart Failure / etiology*
  • Heart Failure / prevention & control
  • Humans
  • Iron / analysis
  • Iron Chelating Agents / administration & dosage
  • Iron Chelating Agents / therapeutic use*
  • Iron Overload / diagnosis*
  • Iron Overload / etiology
  • Iron Overload / pathology
  • Iron Overload / prevention & control
  • Magnetic Resonance Imaging*
  • Male
  • Myocardium / chemistry
  • Myocardium / pathology*
  • Patient Compliance*
  • Predictive Value of Tests
  • Pyridones / administration & dosage
  • Pyridones / therapeutic use
  • ROC Curve
  • Risk
  • Sampling Studies
  • Transfusion Reaction
  • Triazoles / administration & dosage
  • Triazoles / therapeutic use
  • Young Adult
  • beta-Thalassemia / complications
  • beta-Thalassemia / drug therapy
  • beta-Thalassemia / pathology*
  • beta-Thalassemia / therapy

Substances

  • Benzoates
  • Iron Chelating Agents
  • Pyridones
  • Triazoles
  • Deferiprone
  • Iron
  • Deferoxamine
  • Deferasirox