Oxaliplatin induced-neuropathy in digestive tumors

Crit Rev Oncol Hematol. 2014 Jan;89(1):166-78. doi: 10.1016/j.critrevonc.2013.08.009. Epub 2013 Aug 28.

Abstract

Oxaliplatin is one of the main drugs used in digestive tumors treatment. Peripheral neuropathy is a well-recognized dose-limiting toxicity of OXL. Two types of neuropathy have been described with this agent: acute or transient and chronic or persistent, with different etiology, clinical manifestations and prognosis. This paper is an exhaustive review about the main aspects of oxaliplatin induced peripheral neuropathy, focus in clinical features, treatment, prevention strategies and future approach.

Keywords: Digestive tumors; Oxaliplatin; Peripheral neuropathy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Digestive System Neoplasms / complications*
  • Digestive System Neoplasms / drug therapy
  • Humans
  • Incidence
  • Organoplatinum Compounds / administration & dosage
  • Organoplatinum Compounds / adverse effects*
  • Organoplatinum Compounds / therapeutic use
  • Oxaliplatin
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / epidemiology
  • Peripheral Nervous System Diseases / etiology*
  • Peripheral Nervous System Diseases / prevention & control
  • Peripheral Nervous System Diseases / therapy
  • Risk Factors

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Oxaliplatin