We construct a multiregional input-output model for Spain, in order to evaluate the pressures on the water resources, virtual water flows, and water footprints of the regions, and the water impact of trade relationships within Spain and abroad. The study is framed with those interregional input-output models constructed to study water flows and impacts of regions in China, Australia, Mexico, or the UK. To build our database, we reconcile regional IO tables, national and regional accountancy of Spain, trade and water data. Results show an important imbalance between origin of water resources and final destination, with significant water pressures in the South, Mediterranean, and some central regions. The most populated and dynamic regions of Madrid and Barcelona are important drivers of water consumption in Spain. Main virtual water exporters are the South and Central agrarian regions: Andalusia, Castile-La Mancha, Castile-Leon, Aragon, and Extremadura, while the main virtual water importers are the industrialized regions of Madrid, Basque country, and the Mediterranean coast. The paper shows the different location of direct and indirect consumers of water in Spain and how the economic trade and consumption pattern of certain areas has significant impacts on the availability of water resources in other different and often drier regions.