Effects of Nelumbo nucifera stem and leaf tissue extract on the growth of Microcystis aeruginosa and Scenedesmus quadricanda were studied to verify its potential in entriphication control. Five concentrations of Nelumbo nucifera stem and leaf tissue extract were chosen to compare their inhibitory effects on the growth of Microcystis aeruginosa and Scenedesmus quadricanda. The result showed that the leaf extract inhibited the algae bloom more effectively than the stem extract on the whole. When the leaf extract normality was 25 g x L(-1), the highest inhibition rate of Microcystis aeruginosa and Scenedesmus quadricanda was 71.33% and 78.14%, respectively, while for the stem extract, the values were 49.78% and 52.14%. Propanamide was found in both the stem and leaf tissue extracts of Nelumbo nucifera by GC-MS analysis, with concentrations of 1.1 mg x L(-1) and 0.2 mg x L(-1), respectively. The EC50 values of the two kinds of algae were calculated by the probability method.