[Influence of complex deacon-tetra (N1,3-triazole,кN2) copper (II) on the barrier and antioxidant pro people with nasal polyps]

Abstract

Introduction: The aim of this study was synthesized properties 1,2,4-triazole complex ion Cu (II) to determine their potential antioxidant properties, further indication of activity of antioxidant enzymes: catalase (CAT), glutathione peroxidase (GPX) and superoxide dismutase (Cu-Zn SOD) in patients with nasal polyps and the control group.

Material and methods: The study was conducted in a group of 30 patients with nasal polyps aged 48±13.50 (test 1 - group with a compound, test 2 - no relation), and 30 in the control group aged 48±17.90 (control 3 - group with a compound, control 4 - no relation). Blood samples were collected from the antecubital vein into tubes with anticoagulant (heparin sodium). The activity of catalase, superoxide dismutase and glutathione peroxidase were determined in erythrocytes of patients with nasal polyps and the control group (those without inflammatory conditions.

Results: We found that patients with nasal polyps show a decrease in the activity of antioxidant enzymes compared to control: CAT (control 3 - 13.78±6.71 BU/gHb; test 1 - 8.52±7.96 BU/gHb), SOD (control 3 - 1377,614.93±93.44 U/gHb/100ml; test 1 - 867,270.59±49 U/gHb/100ml) and GPX (control 3 - 101.62±8.23 U/gHb; test 1 - 72.97±14.34 U/gHb). Simultaneously, we observed that increasing the activity of antioxidant enzymes compared in the groups control 4 to test 2 (in groups which do not given coordination compound Cu (II): CAT (control 4 - 13.38±7.60 BU/gHb; test 2 - 10.12±3.62 BU/gHb) SOD (control 4 - 1138.88±490.10 U/gHb/100ml; test 2 - 1283.85±439.87 U/gHb/100ml) and GPX (control 4 - 65.18±20.94 U/gHb; test 2 - 90.27±19.42 U/gHb).

Conclusions: The study shows that the complex deacon-tetra (N1,3-triazole,кN2) copper (II) affects the activity of antioxidant enzymes CAT, SOD and GPX.

Keywords: Antioxidants; Complex; Nasal polyps; Triazole; antyoksydanty; kompleks; polipy nosa; triazol.