A case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) related to rufinamide

Dermatol Online J. 2013 Apr 15;19(4):4.

Abstract

Drug Rash (or Reaction) with Eosinophilia and Systemic Symptoms (DRESS) is a potentially life-threatening hypersensitivity reaction to drugs characterized by rash, fever, lymphadenopathy, hematologic abnormalities, and involvement of internal organs. Initially coined in 1996, the term is used to refer to an idiosyncratic reaction to several drugs, the most common of which are carbamazepine, allopurinol, sulfasalazine, and phenobarbital. We report the first case of DRESS related to rufinamide in a ten year old boy with a history of a complex seizure disorder.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Child
  • Drug Hypersensitivity Syndrome / drug therapy
  • Drug Hypersensitivity Syndrome / etiology*
  • Epilepsy, Complex Partial / drug therapy
  • Fructose / analogs & derivatives
  • Fructose / therapeutic use
  • Humans
  • Levetiracetam
  • Male
  • Piracetam / analogs & derivatives
  • Piracetam / therapeutic use
  • Prednisone / therapeutic use
  • Topiramate
  • Triazoles / adverse effects*
  • Triazoles / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Anticonvulsants
  • Triazoles
  • Topiramate
  • Fructose
  • Levetiracetam
  • Prednisone
  • rufinamide
  • Piracetam