Abstract
The effect of the medium pH on accumulation of [3H]-cauloside C by tumor cells, its intracellular localization, and interaction of the glicoside with membranes of tumor cells and liposomes has been studied. The shift towards weakly acids pH leads to the increase in the amount of cauloside C accumulated by tumor cells and changes the pattern of interaction of cauloside C with the membranes.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacokinetics*
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Calorimetry
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Carcinoma, Ehrlich Tumor / metabolism*
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Cell Fractionation
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Cell Membrane / metabolism*
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Drug Interactions
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Hydrogen-Ion Concentration
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Liposomes / pharmacokinetics*
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Mice
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / pharmacokinetics
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Sapogenins
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Viscosity
Substances
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Antineoplastic Agents
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Liposomes
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Sapogenins
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Oleanolic Acid
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cauloside C