Cu(2+)-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang; Sankarprasad Bhuniya; Jongeun Kang; Areum Yeom; Kwan Soo Hong; Jong Seung Kim

doi:10.1021/ol4025293

Cu(2+)-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Org Lett. 2013 Sep 20;15(18):4702-5. doi: 10.1021/ol4025293. Epub 2013 Sep 9.

Authors

Joo Hee Jang¹, Sankarprasad Bhuniya, Jongeun Kang, Areum Yeom, Kwan Soo Hong, Jong Seung Kim

Affiliation

¹ Department of Chemistry, Korea University , Seoul, 136-704, South Korea, Division of MR Research, Korea Basic Science Institute , Cheongwon 363-883, South Korea, and Graduate School of Analytical Science and Technology, Chungnam National University , Daejeon 305-764, South Korea.

PMID: 24015763
DOI: 10.1021/ol4025293

Abstract

A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu(2+) ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Contrast Media / chemical synthesis*
Contrast Media / chemistry
Copper / chemistry*
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / chemistry
Humans
Magnetic Resonance Imaging / methods*
Mice
Microscopy, Fluorescence
Molecular Structure
Solubility
Water / chemistry

Substances

Contrast Media
Fluorescent Dyes
Water
Copper