Anthelmintic profile of methyl 5(6)-(4-methylpiperidin-1-yl) carbonylbenzimidazole-2-carbamate in experimental helminthiases

Indian J Exp Biol. 1990 May;28(5):475-9.

Abstract

Biological evaluation of methyl 5(6)-(4-methylpiperidin-1-yl) carbonylbenzimidazole-2-carbamate against Ancylostoma ceylanicum, Nippostrongylus brasiliensis, Syphacia obvelata, Hymenolepis nana, H. diminuta and Cysticercus fasciolaris in experimental animals is reported. The compound (mg/kg) causes 100% elimination of A. ceylanicum (25 x 1), N. brasiliensis (100 x 1), S. obvelata (50 x 1), H. nana (250 x 3) and C. fasciolaris (50 x 10). It was also effective against the developing larvae (L3, L4 and L5) of A. ceylanicum at a single oral dose of 100 mg/kg. Another study indicated that the compound elicits 100% response within 32 hr of drug administration. The drug is well tolerated and LD50 is greater than 4500 mg/kg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics*
  • Benzimidazoles / pharmacology*
  • Benzimidazoles / toxicity
  • Drug Evaluation, Preclinical
  • Helminthiasis / drug therapy
  • Lethal Dose 50
  • Molecular Structure
  • Piperidines / pharmacology*
  • Piperidines / toxicity

Substances

  • Anthelmintics
  • Benzimidazoles
  • Piperidines
  • methyl 5(6)-(4-methylpiperidin-1-yl)carbonylbenzimidazole-2-carbamate