Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor

Abstract

Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.

Keywords: actinomycetes; bacterial translocase I inhibitor; gene targeting; nucleoside antibiotics; transaldolase.