Selective reduction of amides to amines by boronic acid catalyzed hydrosilylation

Angew Chem Int Ed Engl. 2013 Oct 25;52(44):11577-80. doi: 10.1002/anie.201304495. Epub 2013 Sep 6.

Abstract

Not a 'B'ore! Benzothiophene-based boronic acids catalyze the reduction of tertiary, secondary, and primary amides in the presence of a hydrosilane. The reaction demonstrates good functional-group tolerance.

Keywords: amides; boron; homogeneous catalysis; organocatalysis; reduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amines / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Molecular Structure

Substances

  • Amides
  • Amines
  • Boronic Acids