Fecal microbiota transplantation and donor standardization

Casey Owens; Elizabeth Broussard; Christina Surawicz

doi:10.1016/j.tim.2013.07.003

Fecal microbiota transplantation and donor standardization

Trends Microbiol. 2013 Sep;21(9):443-5. doi: 10.1016/j.tim.2013.07.003.

Authors

Casey Owens¹, Elizabeth Broussard, Christina Surawicz

Affiliation

¹ Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: cowens@medicine.washington.edu.

PMID: 24012274
DOI: 10.1016/j.tim.2013.07.003

Abstract

Clostridium difficile diarrhea is a common and severe infectious disease. Antibiotics, which are standard initial treatment, are less effective for treating refractory or recurrent infection. Fecal microbiota transplantation, where healthy donor stool is transplanted into a patient, is an alternative to antibiotic therapy that requires standardization for donors and patients.

Keywords: Clostridium difficile; diarrhea; fecal microbiota transplant.

MeSH terms

Biological Therapy / standards*
Clostridioides difficile / genetics
Clostridioides difficile / isolation & purification
Clostridioides difficile / physiology*
Diarrhea / microbiology
Diarrhea / therapy*
Enterocolitis, Pseudomembranous / microbiology
Enterocolitis, Pseudomembranous / therapy*
Feces / microbiology*
Humans
Microbiota*