Female predominance of immune response to SSA/Ro antigens and risk of neonatal lupus erythematosus

Br J Dermatol. 1990 Aug;123(2):223-7. doi: 10.1111/j.1365-2133.1990.tb01850.x.

Abstract

Eight-hundred and twenty-five patients attending the hospital with clinical signs and symptoms of collagen diseases were tested for anti-SSA/Ro antibody. The frequency of positivity to SSA/Ro was significantly higher in females, 11.0%, than in males, 3.2% (P less than 0.01). Five babies born to anti-SSA/Ro positive mothers all had neonatal lupus erythematosus and in one there were various cardiac abnormalities.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antinuclear / analysis*
  • Autoantigens / immunology
  • Child
  • Female
  • Humans
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged
  • Pregnancy
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins*
  • Risk Factors
  • Sex Factors

Substances

  • Antibodies, Antinuclear
  • Autoantigens
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoproteins
  • SS-A antibodies
  • SS-A antigen
  • SS-B antibodies