Secondary metabolites from the soft coral Sinularia arborea

Mar Drugs. 2013 Sep 3;11(9):3372-80. doi: 10.3390/md11093372.

Abstract

Two new 13-hydroxycembrane diterpenoids, arbolides A (1) and B (2), along with a known trihydroxysteroid, crassarosterol A (3), were isolated from the soft coral Sinularia arborea. The structures of new cembranes 1 and 2 were elucidated by spectroscopic methods. Steroid 3 was found to exhibit cytotoxicity toward K562 and MOLT-4 leukemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anthozoa / metabolism*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Drug Screening Assays, Antitumor / methods
  • Humans
  • K562 Cells
  • Leukemia / drug therapy

Substances

  • Antineoplastic Agents
  • Diterpenes