Abstract
Two new 13-hydroxycembrane diterpenoids, arbolides A (1) and B (2), along with a known trihydroxysteroid, crassarosterol A (3), were isolated from the soft coral Sinularia arborea. The structures of new cembranes 1 and 2 were elucidated by spectroscopic methods. Steroid 3 was found to exhibit cytotoxicity toward K562 and MOLT-4 leukemia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anthozoa / metabolism*
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Diterpenes / chemistry*
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor / methods
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Humans
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K562 Cells
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Leukemia / drug therapy
Substances
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Antineoplastic Agents
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Diterpenes