[Comparative antioxidant and antihypoxic activities of new 1,4-dihydro-4-oxopyrimidine derivative--compound PDMpT.HCl and mexidol]

E V Petrova; É T Oganesian; I P Kodonidi; E N Zhoglo

[Comparative antioxidant and antihypoxic activities of new 1,4-dihydro-4-oxopyrimidine derivative--compound PDMpT.HCl and mexidol]

Eksp Klin Farmakol. 2013;76(6):38-40.

[Article in Russian]

Authors

E V Petrova, É T Oganesian, I P Kodonidi, E N Zhoglo

PMID: 24003490

Abstract

Compound PDMpT.HCI reduces intensity of lipoperoxidation, activates antioxidant system and increases animal life expectancy under hypoxic circumstance.

Publication types

Comparative Study

MeSH terms

Animals
Animals, Outbred Strains
Antioxidants / chemistry
Antioxidants / pharmacology*
Gravitation
Hypoxia-Ischemia, Brain / drug therapy*
Hypoxia-Ischemia, Brain / metabolism
Hypoxia-Ischemia, Brain / physiopathology
Lipid Peroxidation / drug effects
Longevity / drug effects
Male
Mice
Picolines / pharmacology
Pyrimidines / chemistry
Pyrimidines / pharmacology*
Pyrimidinones / chemistry
Pyrimidinones / pharmacology*
Rats
Reperfusion Injury / drug therapy*
Reperfusion Injury / metabolism
Reperfusion Injury / physiopathology
Superoxide Dismutase / metabolism
Toluene / analogs & derivatives*
Toluene / chemistry
Toluene / pharmacology

Substances

2,6-dimethyl-5-phenyl-1-p-tolyl-1H-pyrimidin-4-one
Antioxidants
Picolines
Pyrimidines
Pyrimidinones
emoxypine succinate
Toluene
Superoxide Dismutase