New secoiridoids from the fruits of Ligustrum lucidum Ait with triglyceride accumulation inhibitory effects

Fitoterapia. 2013 Dec:91:107-112. doi: 10.1016/j.fitote.2013.08.022. Epub 2013 Aug 31.

Abstract

Five new secoiridoids, nuzhenal C (1), 6'-O-trans-cinnamoyl iso-8-epikingisidic acid (2), ligulucidumosides A (3), B (4), and C (5), were obtained from the fruits of Ligustrum lucidum Ait. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compound 3 is the first 1-OCH3 substituent secoiridoid obtained from plant kingdom. Furthermore, activity screening results showed that all of the isolates had triglyceride accumulation inhibitory effects in HepG2 cells.

Keywords: HepG2 cells; Ligustrum lucidum; Secoiridoids; Triglyceride accumulation inhibitory effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fruit / chemistry
  • Hep G2 Cells
  • Humans
  • Iridoids / chemistry
  • Iridoids / isolation & purification
  • Iridoids / pharmacology*
  • Ligustrum / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Triglycerides / metabolism*

Substances

  • Iridoids
  • Plant Extracts
  • Triglycerides