Loss of CCR4 antigen expression after mogamulizumab therapy in a case of adult T-cell leukaemia-lymphoma

Br J Haematol. 2013 Dec;163(5):683-5. doi: 10.1111/bjh.12555. Epub 2013 Sep 3.

Authors

Nobuhiro Ohno¹, Seiichiro Kobayashi, Tomohiro Ishigaki, Koichiro Yuji, Masayuki Kobayashi, Koota Sato, Nobukazu Watanabe, Arinobu Tojo, Kaoru Uchimaru

Affiliation

¹ Department of Haematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. nobuohno@ims.u-tokyo.ac.jp.

PMID: 23998261
DOI: 10.1111/bjh.12555

No abstract available

Keywords: CC chemokine receptor 4; adult T-cell leukaemia-lymphoma; flow cytometry; mogamulizumab; monoclonal antibody.

Publication types

Case Reports
Letter

MeSH terms

Antibodies, Monoclonal, Humanized / pharmacology
Antibodies, Monoclonal, Humanized / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carboplatin / administration & dosage
Cisplatin / administration & dosage
Clone Cells / metabolism
Cyclophosphamide / administration & dosage
Down-Regulation / drug effects
Doxorubicin / administration & dosage
Etoposide / administration & dosage
Fatal Outcome
Female
Gene Expression Regulation, Neoplastic / drug effects*
Humans
Leukemia-Lymphoma, Adult T-Cell / drug therapy*
Middle Aged
Neoplasm Proteins / biosynthesis*
Neoplasm Proteins / genetics
Neoplasm Proteins / immunology
Nitrosourea Compounds / administration & dosage
Prednisone / administration & dosage
Receptors, CCR4 / biosynthesis*
Receptors, CCR4 / genetics
Receptors, CCR4 / immunology
Vincristine / administration & dosage
Vindesine / administration & dosage

Substances

Antibodies, Monoclonal, Humanized
CCR4 protein, human
Neoplasm Proteins
Nitrosourea Compounds
Receptors, CCR4
Vincristine
Etoposide
Doxorubicin
Cyclophosphamide
Carboplatin
Cisplatin
Vindesine
ranimustine
Prednisone
mogamulizumab