Abstract
Development of lanthanide-based luminescent "switch-on" systems via azide-alkyne [3+2] cycloaddition is described. We used these for non-specific protein labeling and as tags for specific and selective activity-based protein labeling.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry
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Animals
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Azides / chemistry
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Cattle
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Click Chemistry
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Coordination Complexes / chemistry*
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Cycloaddition Reaction
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Lanthanoid Series Elements / chemistry*
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Papain / chemistry
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Papain / metabolism
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Proteins / chemistry*
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Proteins / metabolism
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Serum Albumin, Bovine / chemistry
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Serum Albumin, Bovine / metabolism
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Spectrometry, Fluorescence
Substances
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Alkynes
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Azides
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Coordination Complexes
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Lanthanoid Series Elements
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Proteins
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Serum Albumin, Bovine
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Papain