Abstract
We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminacrine / chemistry
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DNA / chemistry*
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DNA / metabolism
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Gold / chemistry
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Hydrogen-Ion Concentration
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Ligands
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Metal Nanoparticles / chemistry
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Nucleosomes / metabolism
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Spectrophotometry, Ultraviolet
Substances
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Ligands
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Nucleosomes
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Gold
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Aminacrine
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DNA