Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands

J Inorg Biochem. 2013 Dec:129:1-8. doi: 10.1016/j.jinorgbio.2013.07.033. Epub 2013 Jul 31.

Abstract

Four new compounds of general formula [FeCp(dppe)L][CF3SO3] with L=imidazole substituted ligands, and dppe=ethylenebis(diphenylphosphane) have been synthesized and characterized with the aim to evaluate their anticancer properties. The new compounds were fully characterized by spectroscopic and electrochemical methods and the structure of [Fe(η(5)-C5H5)(dppe)(1-BuIm)] [CF3SO3] (1), [Fe(η(5)-C5H5)(dppe) (ImH)][CF3SO3] (3) and [Fe(η(5)-C5H5)(dppe)(1HmIm)][CF3SO3] (4) (where 1-BuIm=1-butylimidazole, and 1HmIm=N-hydroxymethylimidazole) was determined by X-ray diffraction studies. Apparently, these compounds are the first reported 'Fe(η(5)-C5H5)' half sandwich derivatives presenting high cytotoxic activity against a set a human tumor cell lines predicting their potential value as antitumor drugs.

Keywords: Cyclopentadienyl; Cytotoxicity; Heteroaromatic ligands; Iron; Organometallic; X-ray structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • Cyclopentanes* / chemical synthesis
  • Cyclopentanes* / chemistry
  • Cyclopentanes* / pharmacology
  • Cytotoxins* / chemical synthesis
  • Cytotoxins* / chemistry
  • Cytotoxins* / pharmacology
  • Humans
  • Imidazoles* / chemistry
  • Imidazoles* / pharmacology
  • Iron Compounds* / chemical synthesis
  • Iron Compounds* / chemistry
  • Iron Compounds* / pharmacology
  • Neoplasms / drug therapy*
  • Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Cyclopentanes
  • Cytotoxins
  • Imidazoles
  • Iron Compounds
  • imidazole