Racial comparison of filaggrin null mutations in asthmatic patients with atopic dermatitis in a US population

J Allergy Clin Immunol. 2013 Nov;132(5):1232-4. doi: 10.1016/j.jaci.2013.07.005. Epub 2013 Aug 28.

Abstract

We examined the association of filaggrin loss-of-function mutations in U.S. atopic patients with asthma. We confirm that only Whites with the R501X mutation and AD have increased risk of asthma.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / complications*
  • Asthma / epidemiology*
  • Asthma / genetics
  • Dermatitis, Atopic / complications*
  • Female
  • Filaggrin Proteins
  • Humans
  • Intermediate Filament Proteins / genetics
  • Male
  • Mutation
  • Odds Ratio
  • United States / epidemiology
  • United States / ethnology

Substances

  • FLG protein, human
  • Filaggrin Proteins
  • Intermediate Filament Proteins