Prevalence and molecular typing of oxacillin-susceptible mecA-positive Staphylococcus aureus from multiple hospitals in China

Diagn Microbiol Infect Dis. 2013 Nov;77(3):267-9. doi: 10.1016/j.diagmicrobio.2013.07.001. Epub 2013 Aug 28.

Abstract

Among 1588 non-duplicated Staphylococcus aureus isolates from 10 cities in China, 60 isolates were susceptible to oxacillin (MIC50: 1 μg/mL; MIC90: 2 μg/mL) but were mecA-positive. Twenty-one spa and 5 staphylococcal cassette chromosome mec (SCCmec) types were detected, and combined with multilocus sequence typing method, ST59-t437-SCCmecIV/V was the predominant clone (26.7%, 16/60).

Keywords: Oxacillin; Staphylococcus aureus; mecA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • China / epidemiology
  • Hospitals
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Epidemiology
  • Molecular Typing*
  • Oxacillin / pharmacology*
  • Penicillin-Binding Proteins
  • Prevalence
  • Retrospective Studies
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Protein A / genetics
  • Staphylococcus aureus / classification*
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Penicillin-Binding Proteins
  • Staphylococcal Protein A
  • mecA protein, Staphylococcus aureus
  • Oxacillin