Acremonium sclerotigenum-Acremonium egyptiacum: a multi-resistant fungal pathogen complicating the course of aplastic anaemia

Clin Microbiol Infect. 2014 Jan;20(1):O30-2. doi: 10.1111/1469-0691.12319. Epub 2013 Aug 30.

Abstract

A patient with aplastic anaemia, successively treated with caspofungin then liposomal amphotericin, developed a disseminated infection due to Acremonium, further confirmed as resistant in vitro to these drugs. Successful treatment was achieved with voriconazole. Multiple antifungal treatments may expose to the risk of breakthrough of multi-resistant pathogens in haematology patients.

Keywords: Acremonium; amphotericin B resistance; caspofungin resistance; opportunistic infections; severe aplastic anaemia.

Publication types

  • Case Reports

MeSH terms

  • Acremonium / classification
  • Acremonium / isolation & purification*
  • Adult
  • Amphotericin B / therapeutic use*
  • Anemia, Aplastic / complications*
  • Anemia, Aplastic / microbiology
  • Antifungal Agents / therapeutic use*
  • Caspofungin
  • Drug Resistance, Fungal / drug effects
  • Echinocandins / therapeutic use*
  • Humans
  • Lipopeptides
  • Male
  • Mycoses / drug therapy
  • Mycoses / microbiology*
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / microbiology*
  • Pyrimidines / pharmacology*
  • Pyrimidines / therapeutic use
  • Triazoles / pharmacology*
  • Triazoles / therapeutic use
  • Voriconazole

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Caspofungin
  • Voriconazole