This minireview focuses on recent studies implicating class V myosins in organelle and macromolecule transport within neurons. These studies reveal that class V myosins play important roles in a wide range of fundamental processes occurring within neurons, including the transport into dendritic spines of organelles that support synaptic plasticity, the establishment of neuronal shape, the specification of polarized cargo transport, and the subcellular localization of mRNA.
Keywords: Cell Polarity; Endoplasmic Reticulum (ER); Ionotropic Glutamate Receptors (AMPA, NMDA); Myosin; Neurons; PTEN; Rab Proteins; Receptor Recycling; Synaptic Plasticity; mRNA.