Novel porphyrin-psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

Org Biomol Chem. 2013 Oct 21;11(39):6675-9. doi: 10.1039/c3ob41224e. Epub 2013 Aug 29.

Abstract

A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Catalysis
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Copper / chemistry
  • DNA / chemistry*
  • Ficusin / chemical synthesis*
  • Ficusin / chemistry
  • Ficusin / pharmacology
  • Fluorescence
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Porphyrins / chemical synthesis*
  • Porphyrins / chemistry
  • Porphyrins / pharmacology

Substances

  • Antineoplastic Agents
  • Porphyrins
  • Copper
  • DNA
  • Ficusin