Abstract
A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Catalysis
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Cell Line, Tumor
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Cell Survival / drug effects
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Copper / chemistry
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DNA / chemistry*
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Ficusin / chemical synthesis*
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Ficusin / chemistry
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Ficusin / pharmacology
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Fluorescence
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Porphyrins / chemical synthesis*
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Porphyrins / chemistry
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Porphyrins / pharmacology
Substances
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Antineoplastic Agents
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Porphyrins
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Copper
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DNA
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Ficusin