Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen

Harshal Zope; Christophe Barnier Quer; Paul H H Bomans; Nico A J M Sommerdijk; Alexander Kros; Wim Jiskoot

doi:10.1002/adhm.201300247

Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen

Adv Healthc Mater. 2014 Mar;3(3):343-8. doi: 10.1002/adhm.201300247. Epub 2013 Aug 27.

Authors

Harshal Zope¹, Christophe Barnier Quer, Paul H H Bomans, Nico A J M Sommerdijk, Alexander Kros, Wim Jiskoot

Affiliation

¹ Department of Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands.

PMID: 23983195
DOI: 10.1002/adhm.201300247

Abstract

Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.

Keywords: adjuvants; nanoparticles; peptide amphiphiles; self-assembly; vaccines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / pharmacology*
Animals
Antibodies, Viral / blood
Antigens, Viral / immunology*
CpG Islands*
Humans
Immunoglobulin G / blood
Influenza, Human / prevention & control
Mice, Inbred C57BL
Nanoparticles / chemistry*
Orthomyxoviridae Infections / prevention & control
Peptides / chemistry*
Vaccines / chemistry*
Vaccines / immunology

Substances

Adjuvants, Immunologic
Antibodies, Viral
Antigens, Viral
Immunoglobulin G
Peptides
Vaccines