Enzyme-responsive supramolecular nanovalves crafted by mesoporous silica nanoparticles and choline-sulfonatocalix[4]arene [2]pseudorotaxanes for controlled cargo release

Chem Commun (Camb). 2013 Oct 11;49(79):9033-5. doi: 10.1039/c3cc45216f.

Abstract

Mesoporous silica nanoparticles (MSNs) have been surface-functionalized with choline moieties encircled by sulfonatocalix[4]arenes. Two enzyme cleavable sites are incorporated in the stalks for specific enzymes to regulate the release of loaded cargos from MSNs. These gated materials show a clear enzymatic response and proven orthogonality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Calixarenes / chemistry*
  • Choline / chemistry
  • Enzymes / metabolism*
  • Esterases / metabolism
  • Hydrogen-Ion Concentration
  • Nanoparticles / chemistry*
  • Phenols / chemistry*
  • Porosity
  • Rhodamines / chemistry
  • Rotaxanes / chemistry*
  • Silicon Dioxide / chemistry*
  • Sulfonic Acids / chemistry
  • Surface Properties

Substances

  • Biocompatible Materials
  • Enzymes
  • MCM-41
  • Phenols
  • Rhodamines
  • Rotaxanes
  • Sulfonic Acids
  • calix(4)arene
  • Calixarenes
  • Silicon Dioxide
  • Esterases
  • rhodamine B
  • Choline