Comparison between the EUCAST procedure and the Etest for determination of the susceptibility of Candida species isolates to micafungin

Antimicrob Agents Chemother. 2013 Nov;57(11):5767-70. doi: 10.1128/AAC.01032-13. Epub 2013 Aug 26.

Abstract

We compared the ability of the EUCAST EDef 7.2 and the Etest to detect the susceptibility to micafungin of 160 Candida and non-Candida clinical isolates. Agreement was higher when Etest MICs were obtained after 24 h of incubation; essential agreement was 90%, and categorical agreement was >90%. False susceptibility was seen only for Candida krusei (10%), and false resistance was observed in 6% of the isolates, ranging from 2.6% (C. glabrata) to 13% (C. albicans).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Artifacts
  • Candida / drug effects*
  • Candida / growth & development
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Drug Resistance, Fungal
  • Echinocandins / pharmacology*
  • Humans
  • Lipopeptides / pharmacology*
  • Micafungin
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Micafungin