Synthesis of strongly green-photoluminescent graphene quantum dots for drug carrier

Colloids Surf B Biointerfaces. 2013 Dec 1:112:192-6. doi: 10.1016/j.colsurfb.2013.07.025. Epub 2013 Jul 19.

Abstract

A novel approach has been developed for the preparation of strongly green-photoluminescent graphene quantum dots (GQDs-PEG) which have been surface-passivated by polyethylene glycol. The photoluminescence (PL) quantum yield of the GQDs-PEG with 400 nm excitation was about 18.8%, which was higher than other GQDs reported in the literature. More importantly, the surface-passivated PEG on GQDs can not only enhance PL intensity but also load drug by hydrogen bonding. Moreover, the high specific surface area of GQDs-PEG endowed them high loading capability (2.5 mg/mg) to carry drug. The results demonstrated that the GQDs-PEG were suitable for drug carrier and cell imaging.

Keywords: Drug carrier; Graphene quantum dots; Photoluminescence; Polyethylene glycol; Surface passivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Tracking / methods
  • Doxorubicin / administration & dosage
  • Drug Carriers / chemistry*
  • Graphite / chemistry*
  • Hydrogen-Ion Concentration
  • Luminescence
  • Microscopy, Electron, Transmission
  • Polyethylene Glycols / chemistry
  • Quantum Dots / chemistry*
  • Quantum Dots / ultrastructure
  • Spectrometry, Fluorescence
  • Spectrophotometry
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Drug Carriers
  • Polyethylene Glycols
  • Graphite
  • Doxorubicin