Extracellular lipid metabolism influences the survival of ovarian cancer cells

Biochem Biophys Res Commun. 2013 Sep 20;439(2):280-4. doi: 10.1016/j.bbrc.2013.08.041. Epub 2013 Aug 21.

Abstract

Lysophosphatidic acid (LPA) is an extracellular lipid mediator consisting of a fatty acid and a phosphate group linked to the glycerol backbone. Here, we show that 1-oleoyl- and 1-palmitoyl-LPA, but not 1-stearoyl- or alkyl-LPA, enhance HNOA ovarian cancer cell survival. Other lysophospholipids with oleic or lauric acid, but not stearic acid, also induce the survival effects. HNOA cells have the lipase activities that cleave LPA to generate fatty acid. Oleic acid stimulates HNOA cell survival via increased glucose utilization. Our findings suggest that extracellular lysolipid metabolism might play an important role in HNOA cell growth.

Keywords: Cell survival; Fatty acid; Lysophosphatidic acid; Lysophospholipase; Ovarian cancer cell.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Fatty Acids / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lipid Metabolism
  • Lysophospholipids / genetics
  • Lysophospholipids / metabolism*
  • Ovarian Neoplasms / enzymology
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / metabolism*
  • Ovarian Neoplasms / pathology*
  • Ovary / metabolism*
  • Ovary / pathology*

Substances

  • Fatty Acids
  • Lysophospholipids
  • 1-palmitoyl-lysophosphatidic acid
  • lysophosphatidic acid