Large ulceration of the oropharynx induced by methotrexate-associated lymphoproliferative disorders

Hiroyuki Hanakawa; Yorihisa Orita; Yasuharu Sato; Kinya Uno; Kazunori Nishizaki; Tadashi Yoshino

doi:10.18926/AMO/51072

Large ulceration of the oropharynx induced by methotrexate-associated lymphoproliferative disorders

Acta Med Okayama. 2013;67(4):265-9. doi: 10.18926/AMO/51072.

Authors

Hiroyuki Hanakawa¹, Yorihisa Orita, Yasuharu Sato, Kinya Uno, Kazunori Nishizaki, Tadashi Yoshino

Affiliation

¹ Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

PMID: 23970326
DOI: 10.18926/AMO/51072

Abstract

We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antirheumatic Agents / adverse effects
Arthritis, Rheumatoid / drug therapy*
Humans
Lymphoproliferative Disorders / chemically induced*
Lymphoproliferative Disorders / pathology
Male
Methotrexate / adverse effects*
Oral Ulcer / chemically induced*
Oral Ulcer / pathology
Oropharynx / pathology*

Substances

Antirheumatic Agents
Methotrexate