Abstract
Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
MeSH terms
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Biocompatible Materials / chemistry*
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Biocompatible Materials / metabolism
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Calcium Phosphates / chemistry*
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Calcium Phosphates / metabolism
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Cell Adhesion*
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Cell Proliferation
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Cells, Cultured
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Ceramics / chemistry*
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Ceramics / metabolism
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Click Chemistry
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Durapatite / chemistry*
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Durapatite / metabolism
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Fetus / cytology
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Fetus / metabolism*
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Humans
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Materials Testing
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Molecular Structure
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Osteoblasts / cytology
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Osteoblasts / metabolism*
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Surface Properties
Substances
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Biocompatible Materials
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Calcium Phosphates
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beta-tricalcium phosphate
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Durapatite